{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:11:06Z","timestamp":1790849466029,"version":"4.1.0"},"reference-count":0,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastrointest Tumors"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Pancreatic cancer is the fourth leading cause of cancer-related deaths worldwide. Chronic pancreatitis is frequently observed in patients with pancreatic cancer, and a significant relationship between orodigestive cancer-related deaths and chronic periodontitis has been detected. &lt;i&gt;Porphyromonas gingivalis&lt;\/i&gt;, &lt;i&gt;Tannerella forsythia&lt;\/i&gt;, and &lt;i&gt;Treponema denticola&lt;\/i&gt;, collectively called the Red complex, are the major pathogens responsible for chronic periodontitis and secrete peptidylarginine deiminase. Anti-&lt;i&gt;P. gingivalis&lt;\/i&gt; antibodies titers are higher in pancreatic cancer patients than in healthy subjects. &lt;b&gt;&lt;i&gt;Summary:&lt;\/i&gt;&lt;\/b&gt; This review examines the association between oral bacteria and the etiology of pancreatic cancer. &lt;b&gt;&lt;i&gt;Key Message:&lt;\/i&gt;&lt;\/b&gt; High rates of tumor suppressor gene &lt;i&gt;p53&lt;\/i&gt; mutations, particularly &lt;i&gt;p53&lt;\/i&gt; arginine mutations, were detected in pancreatic cancer patients. &lt;i&gt;K-ras&lt;\/i&gt; arginine mutations were detected in patients with pancreatic cancer. Oral bacteria peptidylarginine deiminases might lead to the &lt;i&gt;p53&lt;\/i&gt; and &lt;i&gt;K-ras&lt;\/i&gt; point mutations by degrading arginine. &lt;b&gt;&lt;i&gt;Practical Implications:&lt;\/i&gt;&lt;\/b&gt; Oral bacteria are likely to be responsible for the development of pancreatic cancer. If this hypothesis is true, it may reveal the real cause of pancreatic cancer, which is a fatal disease.<\/jats:p>","DOI":"10.1159\/000452708","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T17:01:38Z","timestamp":1480006898000},"page":"125-127","source":"Crossref","is-referenced-by-count":46,"title":["Periodontal Pathogens in the Etiology of Pancreatic Cancer"],"prefix":"10.1159","volume":"3","author":[{"given":"Mesut","family":"\u00d6\u011frendik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,11,25]]},"container-title":["Gastrointestinal Tumors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452708","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T13:24:15Z","timestamp":1745414655000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000452708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2017,3,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000452708","archive":["Portico"],"relation":{},"ISSN":["2296-3774","2296-3766"],"issn-type":[{"value":"2296-3774","type":"print"},{"value":"2296-3766","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}