{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:03:43Z","timestamp":1762459423680,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroimmunomodulation"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; Cytokines play an integral role in sleep\/wake regulation. The objective of this study was to identify how total sleep deprivation affects cytokine levels. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Male C57BL\/6 mice were subjected to 48 h of total sleep deprivation produced by brief rotation of activity wheels or 3 different controls: home cage, a sedentary wheel, or forced activity. In addition, the serum levels of cytokines were analyzed using a mouse magnetic bead-based multiplex immunoassay. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The concentrations of some cytokines (fibroblast growth factor-basic [FGF-basic], leukemia inhibitory factor [LIF], and monokine induced by interferon-&amp;#x03B3; [MIG]) decreased significantly after total sleep deprivation. However, other cytokines (macrophage colony-stimulating factor, macrophage inflammatory protein-2, platelet-derived growth factor-bb, vascular endothelial growth factor) did not show any significant difference. Serum corticosterone levels did not differ significantly among the groups. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The biochemical mechanisms responsible for sleep regulation are very complex. These results suggest the involvement of 3 cytokines (FGF-basic, LIF, and MIG) in sleep\/wake regulation.<\/jats:p>","DOI":"10.1159\/000452713","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T22:01:35Z","timestamp":1481234495000},"page":"244-249","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Total Sleep Deprivation on Mouse Cytokine Levels"],"prefix":"10.1159","volume":"23","author":[{"given":"Lin","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,12,9]]},"container-title":["Neuroimmunomodulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452713","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452713","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:24:17Z","timestamp":1745429057000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000452713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,1,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000452713","archive":["Portico"],"relation":{},"ISSN":["1021-7401","1423-0216"],"issn-type":[{"type":"print","value":"1021-7401"},{"type":"electronic","value":"1423-0216"}],"subject":[],"published":{"date-parts":[[2016]]}}}