{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:40:19Z","timestamp":1786624819104,"version":"build-2736575974"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Recent updates to the Nikkiso Aquarius continuous renal replacement therapy (CRRT) platform allowed us to develop a post-dilution protocol for regional citrate anticoagulation (RCA) using standard bicarbonate buffered, calcium containing replacement solution with acid citrate dextrose formula-A as a citrate source. Our objective was to demonstrate that the protocol was safe and effective. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Prospective audit of consecutive patients receiving RCA for CRRT within intensive care unit, who were either contraindicated to heparin or had poor filter lifespan (&lt;12 h for 2 consecutive filters) on heparin. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We present the first 29 patients who used 98 filters. After excluding \u2018non-clot' filter loss, 50% had a duration of &gt;27 h. Calcium supplementation was required for 30 (30%) filter circuits, in 17 of 29 (58%) patients. One patient discontinued the treatment due to metabolic alkalosis, but there were no adverse bleeding events. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Post-dilution RCA system is effective and simple to use on the Aquarius platform and results in comparable filter life for patients relatively contraindicated to heparin.<\/jats:p>","DOI":"10.1159\/000452755","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T22:01:44Z","timestamp":1479506504000},"page":"349-355","source":"Crossref","is-referenced-by-count":16,"title":["Implementation of a Simplified Regional Citrate Anticoagulation Protocol for Post-Dilution Continuous Hemofiltration Using a Bicarbonate Buffered, Calcium Containing Replacement Solution"],"prefix":"10.1159","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7223-0348","authenticated-orcid":false,"given":"Christopher J.","family":"Kirwan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Hutchison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif","family":"Ghabina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Schwarze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Beane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Ramsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5002-2721","authenticated-orcid":false,"given":"John R.","family":"Prowle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,11,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.300"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-4099-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1299-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0472-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ndtplus\/sfp136"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/cc11645"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000323"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg488"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053\/jcrc.2003.50006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-232"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1066-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181953c5e"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2012.757823"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1143-y"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452755","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452755","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:56:48Z","timestamp":1745427408000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000452755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,12,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000452755","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.4239446","asserted-by":"subject"}]},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}