{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:16:20Z","timestamp":1762506980873,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Caries Res"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Abrasives may counteract the efficacy of anti-erosion toothpastes either due to physical effects or due to interaction with active agents. This study aimed to investigate whether the amount of abrasives is a determinant for the efficacy of Sn&lt;sup&gt;2+&lt;\/sup&gt;-containing toothpastes with or without chitosan additive. Enamel samples were eroded (0.50 wt% citric acid, pH 2.5; 6 \u00d7 2 min\/day) on a shaking desk - 30\/min in experiment 1 (E1) and 35\/min in experiments 2 (E2) and 3 (E3) - and immersed in toothpaste slurries (2 \u00d7 2 min). Half of the samples were additionally brushed (15 s, load 200 g) within the immersion time. The toothpastes contained 0, 5, 10, 15, and 20% silica. In E1 and E2 the active ingredients were F&lt;sup&gt;-&lt;\/sup&gt; (700 ppm as amine fluoride, 700 ppm as NaF) and Sn&lt;sup&gt;2+&lt;\/sup&gt; (3,500 ppm as SnCl&lt;sub&gt;2&lt;\/sub&gt;); in E3 chitosan (0.5%) was additionally added. The placebo contained 20% silica. Tissue loss was determined profilometrically. In E1, slurries completely inhibited tissue loss; distinct surface deposits occurred. With brushing, tissue loss significantly increased up to an abrasive content of 10%, but decreased significantly with higher amounts; 20% silica revealed similar values as the abrasive-free formulation. In E2, all slurries inhibited tissue loss distinctly irrespective of the amounts of abrasives. With brushing, a similar trend as in E1 was observed but with much less efficacy. The chitosan-containing formulations in E3 were much more effective; similar results as in E1 were found. In conclusion, the amount of abrasives had no effect when toothpastes were applied as slurries, but played an important role with brushing.<\/jats:p>","DOI":"10.1159\/000452867","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T22:03:15Z","timestamp":1482184995000},"page":"52-57","source":"Crossref","is-referenced-by-count":18,"title":["Do Abrasives Play a Role in Toothpaste Efficacy against Erosion\/Abrasion?"],"prefix":"10.1159","volume":"51","author":[{"given":"Carolina","family":"Ganss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maike","family":"M\u00f6llers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Schlueter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1634-x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1021\/la00041a027"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/134350"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/KEM.404.23"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1021\/la0511844"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000334318"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000350475"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2012.08.005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000260937"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2009.06.006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2007.01.003"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1021\/ma0303263"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1021\/la702653m"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002279.pub2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nature01970"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2009.00647.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-0941-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2005.00210.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2006.02.027"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2007.00454.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-009-0288-y"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000325946"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1080\/00016350802195041"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2006.00354.x"}],"container-title":["Caries Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452867","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452867","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:57:29Z","timestamp":1745427449000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000452867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,20]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,3,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000452867","archive":["Portico"],"relation":{},"ISSN":["0008-6568","1421-976X"],"issn-type":[{"type":"print","value":"0008-6568"},{"type":"electronic","value":"1421-976X"}],"subject":[],"published":{"date-parts":[[2016,12,20]]}}}