{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:53:42Z","timestamp":1783486422403,"version":"3.55.0"},"reference-count":18,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":3329,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Considerable variations in diagnosis and therapeutic practices are reported for hyperthyroidism (HT) between countries. Methods: A clinical study was conducted among a representative sample of 263 endocrinologists in France. All consecutive patients seen for HT during the study period were included. Diagnosis and treatment modalities were recorded from hyperthyroid patients with Graves disease (GD, n = 802), multinodular goiter (MNG, n = 121), and toxic adenoma (TA, n = 69). Results: Antithyroid antibodies were measured in half of the population (anti-TPO in 48.5% and anti-TSH receptor in 57.8%). Patients had thyroid ultrasonography and scintigraphy in 93.8 and 40.3%, respectively. Therapeutic management depended on the etiology: for the first episode of GD, antithyroid drugs (ATDs) were the first-line treatment in 91% of the patients, combined with surgery in 6.1% and with radioiodine in 2.9%. Surgery was preferred to radioiodine in MNG (52.6 vs. 22.4%) and TA (59.1 vs. 24.2%). Euthyroid status was achieved after 3 months in 64.4% of GD. A \u201cblock and replace\u201d protocol was used in 41.2% of patients. After 3 months, 73% of patients were euthyroid in the \u201cblock and replace\u201d group compared to 56.2% in the group with ATDs alone (p = 0.009). For MNG and TA, more than 75% of patients were euthyroid at the 3-month follow-up. Conclusions: Large discrepancies remain between clinical practice and international guidelines. These results should boost efforts to improve adherence to these guidelines.<\/jats:p>","DOI":"10.1159\/000453260","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T17:01:28Z","timestamp":1483549288000},"page":"152-159","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":18,"title":["Survey of Clinical Practice Patterns in the Management of 992 Hyperthyroid Patients in France"],"prefix":"10.1530","volume":"6","author":[{"given":"Bernard","family":"Goichot","sequence":"first","affiliation":[{"name":"1Department of Internal Medicine, Endocrinology and Nutrition, H\u00f4pitaux Universitaires de Strasbourg"},{"name":"2FMTS, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Strasbourg, Strasbourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Bou\u00e9e","sequence":"additional","affiliation":[{"name":"3CEMKA, Bourg La Reine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Castello-Bridoux","sequence":"additional","affiliation":[{"name":"4Medical Affairs Department, Merck Serono, Lyon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Caron","sequence":"additional","affiliation":[{"name":"5Department of Endocrinology, Metabolic Diseases and Nutrition, P\u00f4le Cardio-Vasculaire et M\u00e9tabolique, CHU Larrey"},{"name":"6Inserm U1037, Universit\u00e9 Paul Sabatier, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2017,1,5]]},"reference":[{"key":"2026070712492105900_ref1","doi-asserted-by":"crossref","unstructured":"Bahn RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, Laurberg P, McDougall IR, Montori VM, Rivkees SA, Ross DS, Sosa JA, Stan MN: Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid 2011;21:593-646.10.1089\/thy.2010.041721510801","DOI":"10.1089\/thy.2010.0417"},{"key":"2026070712492105900_ref2","doi-asserted-by":"crossref","unstructured":"Kahaly GJ, Bartalena L, Heged\u00fcs L: The American Thyroid Association\/American Association of Clinical Endocrinologists guidelines for hyperthyroidism and other causes of thyrotoxicosis: a European perspective. Thyroid 2011;21:585-591.10.1089\/thy.2011.2106.ed321663420","DOI":"10.1089\/thy.2011.2106.ed3"},{"key":"2026070712492105900_ref3","doi-asserted-by":"crossref","unstructured":"Franklyn JA: What is the role of radioiodine uptake measurement and thyroid scintigraphy in the diagnosis and management of hyperthyroidism? 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