{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:34:39Z","timestamp":1773434079460,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Immediate type hypersensitivity reactions due to heparins are rare, and the exact immunologic pathomechanism has not been identified so far. In our 2 case reports, we describe first a 50-year-old female who received dalteparin (Fragmin\u00ae) and developed signs of an immediate type hypersensitivity reaction. The personal history revealed a previous application of dalteparin (Fragmin\u00ae). Evaluation with a skin prick test showed positive results for dalteparin. The second case deals with a 73-year-old female with a suspected immediate type reaction after the administration of dalteparin (Fragmin\u00ae). A skin prick test was negative but intracutaneous tests showed a positive reaction to the causative agent. Both cases indicated cross-reactivity reactions for low-molecular-weight heparin (LMWH) but not for unfractioned heparin (UFH) or fondaparinux. In conclusion, our case reports including a review of published cases of immediate type hypersensitivity reactions after the application of heparins illustrate this rare complication. Mostly, the causative agent can be identified with a skin test, which is highly suggestive of an IgE-mediated reaction. Therapeutic alternatives for patients with sensitization to an LMWH are UFH and fondaparinux. Both agents have a small risk of cross-reactivity compared to heparins of the same substance class.<\/jats:p>","DOI":"10.1159\/000453525","type":"journal-article","created":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T22:01:26Z","timestamp":1483480886000},"page":"285-289","source":"Crossref","is-referenced-by-count":14,"title":["Immediate Type Hypersensitivity to Heparins: Two Case Reports and a Review of the Literature"],"prefix":"10.1159","volume":"171","author":[{"given":"Philipp","family":"Cesana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas J.","family":"Bircher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,1,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-01-0032"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp052967"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2174\/138161208786369768"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0803200"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60409-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh071"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-6-44"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02129.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0546(03)79206-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1160\/TH05-03-0673"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01063.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-9-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000152"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e31818def58"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01932.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00373.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/18877"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05321.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000198992.18384.5a"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s40629-015-0048-2"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/453525","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/171\/3-4\/285\/3906625\/000453525.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/171\/3-4\/285\/3906625\/000453525.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:01:54Z","timestamp":1745427714000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000453525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":20,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2017,1,17]]},"published-print":{"date-parts":[[2016,12,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000453525","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}