{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:13:21Z","timestamp":1783448001346,"version":"3.55.0"},"reference-count":18,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":3285,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Introduction: Amiodarone, used for the management of tachyarrhythmias, is associated with both hypothyroidism and thyrotoxicosis. Total thyroidectomy is an effective procedure for promptly reducing circulating thyroid hormone levels. It has been proposed in patients who have severe amiodarone-induced thyrotoxicosis (AIT) or are refractory to medical therapy, or when such therapy is contraindicated. Therapeutic plasma exchange (TPE) may be considered as a pretreatment for restoring a euthyroid state preoperatively, thereby reducing a patient's symptoms and the potential perioperative risk associated with thyrotoxicosis. Case Report: We describe the case of a 62-year-old man with type 2 AIT who presented with severe unremitting thyrotoxicosis after 8 weeks of medical therapy with glucocorticosteroids, thiamazole, and potassium perchlorate. Given the severity of his presentation, a total thyroidectomy was indicated. TPE was performed preoperatively and was successful in rapidly restoring euthyroidism. This dramatically improved the patient's symptoms which had been suggestive of ischemic heart disease. Subsequently, the patient underwent total thyroidectomy under general anesthesia without any major complications. Conclusion: TPE is successful in rapidly restoring a clinical and biochemical euthyroid state, and may be used to decrease the perioperative risks associated with thyroidectomy in patients with life-threatening thyrotoxicosis or in cases refractory to medical treatment.<\/jats:p>","DOI":"10.1159\/000453578","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T17:01:22Z","timestamp":1487350882000},"page":"108-112","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":13,"title":["Successful Pretreatment Using Plasma Exchange before Thyroidectomy in a Patient with Amiodarone-Induced Thyrotoxicosis"],"prefix":"10.1530","volume":"6","author":[{"given":"Annelies","family":"Tonnelier","sequence":"first","affiliation":[{"name":"1Departments of Endocrinology and General Internal Medicine, Algemeen Ziekenhuis Sint-Elisabeth Zottegem, Zottegem, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"de Filette","sequence":"additional","affiliation":[{"name":"1Departments of Endocrinology and General Internal Medicine, Algemeen Ziekenhuis Sint-Elisabeth Zottegem, Zottegem, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"De Becker","sequence":"additional","affiliation":[{"name":"2Departments of Hematology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Deweer","sequence":"additional","affiliation":[{"name":"3Department of Endocrinology and Diabetology, Algemeen Ziekenhuis Sint-Elisabeth Zottegem, Zottegem, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Velkeniers","sequence":"additional","affiliation":[{"name":"1Departments of Endocrinology and General Internal Medicine, Algemeen Ziekenhuis Sint-Elisabeth Zottegem, Zottegem, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2017,2,18]]},"reference":[{"key":"2026070712484290400_ref1","doi-asserted-by":"crossref","unstructured":"Martino E, Bartalena L, Bogazzi F, Braverman LE: The effects of amiodarone on the thyroid. Endocr Rev 2001;22:240-254.","DOI":"10.1210\/edrv.22.2.0427"},{"key":"2026070712484290400_ref2","doi-asserted-by":"crossref","unstructured":"Eskes SA, Wiersinga WM: Amiodarone and thyroid. Best Pract Res Clin Endocrinol Metab 2009;23:735-751.","DOI":"10.1016\/j.beem.2009.07.001"},{"key":"2026070712484290400_ref3","unstructured":"Bogazzi F, Bartalena L, Martino E: Approach to the patient with amiodarone-induced thyrotoxicosis. J Clin Endocrinol Metab 2010;95:2529-2535."},{"key":"2026070712484290400_ref4","doi-asserted-by":"crossref","unstructured":"Bahn RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, Laurberg P, McDougall IR, Montori VM, Rivkees SA, Ross DS, Sosa JA, Stan MN: Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Endocr Pract 2011;17:456-520.","DOI":"10.4158\/EP.17.3.456"},{"key":"2026070712484290400_ref5","doi-asserted-by":"crossref","unstructured":"Tanda ML, Piantanida E, Lai A, Liparulo L, Sassi L, Bogazzi F, Wiersinga WM, Braverman LE, Martino E, Bartalena L: Diagnosis and management of amiodarone-induced thyrotoxicosis: similarities and differences between North American and European thyroidologists. Clin Endocrinol 2008;69:812-818.","DOI":"10.1111\/j.1365-2265.2008.03268.x"},{"key":"2026070712484290400_ref6","doi-asserted-by":"crossref","unstructured":"Franklyn JA, Boelaert K: Thyrotoxicosis. Lancet 2012;379:1155-1166.","DOI":"10.1016\/S0140-6736(11)60782-4"},{"key":"2026070712484290400_ref7","doi-asserted-by":"crossref","unstructured":"Lambert C, Gericke M, Smith R, Hermans C: Plasma extraction rate and collection efficiency during therapeutic plasma exchange with Spectra OPTIA in comparison with Haemonetics MCS+. J Clin Apher 2011;26:17-22.","DOI":"10.1002\/jca.20271"},{"key":"2026070712484290400_ref8","doi-asserted-by":"crossref","unstructured":"Tomisti L, Materazzi G, Bartalena L, Rossi G, Marchello A, Moretti M, De Napoli L, Mariotti R, Miccoli P, Martino E, Bogazzi F: Total thyroidectomy in patients with amiodarone-induced thyrotoxicosis and severe left ventricular systolic dysfunction. J Clin Endocrinol Metab 2012;97:3515-3521.","DOI":"10.1210\/jc.2012-1797"},{"key":"2026070712484290400_ref9","doi-asserted-by":"crossref","unstructured":"Gough J, Gough IR: Total thyroidectomy for amiodarone-associated thyrotoxicosis in patients with severe cardiac disease. World J Surg 2006;30:1957-1961.","DOI":"10.1007\/s00268-005-0673-x"},{"key":"2026070712484290400_ref10","doi-asserted-by":"crossref","unstructured":"Houghton SG, Farley DR, Brennan MD, van Heerden JA, Thompson GB, Grant CS: Surgical management of amiodarone-associated thyrotoxicosis: Mayo Clinic experience. World J Surg 2004;28:1083-1087.","DOI":"10.1007\/s00268-004-7599-6"},{"key":"2026070712484290400_ref11","doi-asserted-by":"crossref","unstructured":"Hamoir E, Meurisse M, Defechereux T, Joris J, Vivario J, Hennen G: Surgical management of amiodarone-associated thyrotoxicosis: too risky or too effective? World J Surg 1998;22: 537-542.","DOI":"10.1007\/PL00024613"},{"key":"2026070712484290400_ref12","doi-asserted-by":"crossref","unstructured":"Shinall MC Jr, Broome JT, Nookala R, Shinall JB, Kiernan C, Parks L 3rd, Solorzano CC: Total thyroidectomy for Graves' disease: compliance with American Thyroid Association guidelines may not always be necessary. Surgery 2013;154:1009-1015.","DOI":"10.1016\/j.surg.2013.04.064"},{"key":"2026070712484290400_ref13","doi-asserted-by":"crossref","unstructured":"Ezer A, Caliskan K, Parlakgumus A, Belli S, Kozanoglu I, Yildirim S: Preoperative therapeutic plasma exchange in patients with thyrotoxicosis. 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