{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T18:32:50Z","timestamp":1784745170221,"version":"3.55.0"},"reference-count":12,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T00:00:00Z","timestamp":1482969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T00:00:00Z","timestamp":1482969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The anterior chamber has been shown by pharmacokinetic studies to represent a sanctuary never achieving a tumoricidal dose with the present administration routes, such as systemic, intra-arterial, or intravitreal injections. &lt;b&gt;&lt;i&gt;Method:&lt;\/i&gt;&lt;\/b&gt; A novel intracameral chemotherapy technique is described to control aqueous seeding in a pilot unilateral group E retinoblastoma case with primary aqueous seeding. Anterior segment toxicity was carefully monitored. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Control of the retinal tumor and vitreous seeding was achieved by intra-arterial and intravitreal chemotherapies. Sterilization of the aqueous was achieved after a first cycle of 7 melphalan injections in the anterior chamber, but relapse was noted 3.5 months later. This relapse was finally controlled with a second cycle of 6 intracameral injections targeting the posterior chamber. Corneal endothelial cell density remained stable over the injection period. Heterochromia and a progressive cataract developed, which required cataract surgery. At 5 years' follow-up, the patient is tumor free with normal vision (20\/20 in both eyes), full binocularity, and no metastasis. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The present bicameral injection technique appears to be safe and effective with limited toxicity. Melphalan-induced side effects were noted on the iris and lens but with no impact on the final visual function.<\/jats:p>","DOI":"10.1159\/000453617","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T22:03:12Z","timestamp":1482962592000},"page":"149-155","source":"Crossref","is-referenced-by-count":53,"title":["Intracameral Chemotherapy (Melphalan) for Aqueous Seeding in Retinoblastoma: Bicameral Injection Technique and Related Toxicity in a Pilot Case Study"],"prefix":"10.1159","volume":"3","author":[{"given":"Francis L.","family":"Munier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claire","family":"Gaillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Decembrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9846-6682","authenticated-orcid":false,"given":"Massimo","family":"Bongiovanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Beck-Popovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,12,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3109\/13816810.2014.973045"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.12.014"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-301450"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.09.040"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(87)33437-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.044"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.07.003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjopt.2013.06.006"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318203c101"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-301016"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2015.0088"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000167"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/453617","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/453617","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/453617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:03:10Z","timestamp":1745427790000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000453617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,29]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,7,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000453617","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.4499123","asserted-by":"subject"}]},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"value":"2296-4681","type":"print"},{"value":"2296-4657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,29]]}}}