{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:26:36Z","timestamp":1782955596151,"version":"3.54.5"},"reference-count":6,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T00:00:00Z","timestamp":1484006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T00:00:00Z","timestamp":1484006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>Papular epidermal nevus with \u201cskyline\u201d basal cell layer (PENS) is a very rare type of keratinocytic nevus and is associated with extracutaneous findings such as neurological symptoms in about 50% of the cases. Therefore, it is also referred to as PENS syndrome. Clinically visible hyperkeratotic papules and plaques already appear at birth or shortly thereafter, while neurological symptoms such as epilepsy and mental retardation manifest themselves during childhood. Genetics suggests gonadal mosaicism as a possible cause for the disease. Another hypothesis is that genetic mutation can occur in a mendelian trait or through a paradominant inheritance.<\/jats:p>","DOI":"10.1159\/000454757","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T22:01:29Z","timestamp":1484085689000},"page":"1-5","source":"Crossref","is-referenced-by-count":6,"title":["Papular Epidermal Nevus with \u201cSkyline\u201d Basal Cell Layer Syndrome \u2013 Natural Course: Case Report and Literature Review"],"prefix":"10.1159","volume":"9","author":[{"given":"Carole\u00a0Anouk","family":"Zahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Itin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,1,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000336794"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12141"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.02.054"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12251"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2012.01830.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31421"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/454757","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/454757","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/454757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:03:59Z","timestamp":1745427839000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000454757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,10]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,4,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000454757","archive":["Portico"],"relation":{},"ISSN":["1662-6567"],"issn-type":[{"value":"1662-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,10]]}}}