{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:39:51Z","timestamp":1777700391398,"version":"3.51.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Nephrol Dial"],"abstract":"<jats:p>Pregnancy-associated thrombotic microangiopathy is a very rare condition; however, it significantly increases fetal or maternal morbidity and mortality. Pregnancy may trigger atypical hemolytic uremic syndrome (aHUS) or thrombotic thrombocytopenic purpura. The risk for pregnancy-associated aHUS is highest during the second pregnancy. The outcome is usually poor with 50\u201360% mortality; renal dysfunction and hypertension are the rule in those who survive the acute episode. After the development of complement regulation mechanisms and aHUS pathogenesis, eculizumab has been widely used as a first-line treatment in aHUS. Eculizumab has been produced to minimize immunogenicity and Fc-mediated functions, including recruitment of inflammatory cells and complement activation, and using eculizumab in first-line treatment improves kidney function. Recent studies showed that early diagnosis and rapid use of eculizumab in first-line treatment improve outcomes. We demonstrate a case with pregnancy-triggered aHUS occurring in the second trimester, who was successfully treated and delivered a healthy baby under eculizumab treatment.<\/jats:p>","DOI":"10.1159\/000454946","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T22:01:37Z","timestamp":1482271297000},"page":"143-148","source":"Crossref","is-referenced-by-count":21,"title":["Pregnant Woman with Atypical Hemolytic Uremic Syndrome Delivered a Healthy Newborn under Eculizumab Treatment"],"prefix":"10.1159","volume":"6","author":[{"given":"Erol","family":"Demir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil","family":"Yazici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin","family":"Ozluk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isin","family":"Kilicaslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aydin","family":"Turkmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-144691"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009070706"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208981"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0808527"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.214"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08099.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502950"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-015-0173-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfs185"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1970-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31828e2612"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-1-201307020-00023"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-8-307"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1579539"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.275"}],"container-title":["Case Reports in Nephrology and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/454946","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/454946","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/454946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:05:46Z","timestamp":1745427946000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000454946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,20]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,12,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000454946","archive":["Portico"],"relation":{},"ISSN":["2296-9705"],"issn-type":[{"value":"2296-9705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,20]]}}}