{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:51:55Z","timestamp":1778356315863,"version":"3.51.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Sleep-disordered breathing (SDB) is highly prevalent in patients with heart failure (HF), and is known to be associated with a worse prognosis. The severity of central sleep apnea is thought to mirror cardiac dysfunction. The novel angiotensin receptor-neprilysin inhibitor (ARNi) sacubitril has been shown to improve HF, but a relationship between treatment with ARNi and the severity of SDB has not yet been investigated. We report the case of a 71-year-old male with HF and SDB. Treatment with sacubitril\/valsartan was associated with improved cardiac function, as shown by a reduction in the level of N-terminal prohormone of brain natriuretic peptide from 3,249 to 1,720 pg\/mL, and an improvement in left-ventricular ejection fraction from 30 to 35%. This was accompanied by a marked reduction in the apnea-hypopnea index (from 41 to 19\/h). To the best of our knowledge, this is the first case to document parallel improvements in HF and SDB after the initiation of ARNi treatment.<\/jats:p>","DOI":"10.1159\/000455118","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T22:02:10Z","timestamp":1487023330000},"page":"96-99","source":"Crossref","is-referenced-by-count":15,"title":["Resolution of Cheyne-Stokes Respiration after Treatment of Heart Failure with Sacubitril\/Valsartan: A First Case Report"],"prefix":"10.1159","volume":"137","author":[{"given":"Henrik","family":"Fox","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bitter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Horstkotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Oldenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,2,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.567"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq183"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2006.08.003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2014.06.063"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.01.084"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409077"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-014-4063-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv624"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7633695"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.12.1574"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-015-1300-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-016-0970-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.168"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200927"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-014-0784-1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.73.3.237"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/455118","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/455118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/455118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:07:18Z","timestamp":1745428038000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000455118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,5,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000455118","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}