{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T01:38:06Z","timestamp":1783993086649,"version":"3.55.0"},"reference-count":0,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Introduction:<\/i><\/b> The study aimed to explore clinical influence of prostatic stones on lower urinary tract symptoms (LUTS), seminal plasma cytokines, and serum biomarkers. <b><i>Materials and Methods:<\/i><\/b> A total of 70 men aged \u226450 years with LUTS divided into 2 groups: group with stones (GSt) and group without prostatic stones (GNoSt). All subjects completed the International Prostate Symptom Score (IPSS) questionnaire and National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scoring questionnaire. Pre- and post-prostate massage test and uroflowmetry were performed. The serum concentration of total prostate specific antigen (PSA), free PSA, and free\/total PSA (f\/t PSA) ratio, seminal concentration of cytokines interleukin (IL)-1\u03b2, IL-6, IL-8, IL-10, IL-12p70, and tumor necrosis factor-alpha were measured. <b><i>Results:<\/i><\/b> GSt subjects had significantly more severe symptoms based on IPSS answers (<i>p<\/i> = 0.0289). All domains in NIH-CPSI scores were significantly higher in the GSt group: pain (<i>p<\/i> = 0.001), urinary symptoms (<i>p<\/i> = 0.023), quality of life (<i>p<\/i> = 0.008), and with overall (<i>p<\/i> = 0.003). GSt subjects also had significantly lower maximum urinary flow (Qmax; <i>p<\/i> = 0.011), lower f\/t PSA ratio (<i>p<\/i> = 0.048), and higher concentration of IL-1\u03b2 (<i>p<\/i> = 0.011) and IL-8 (<i>p<\/i> = 0.001). <b><i>Conclusions:<\/i><\/b> Prostatic stones may influence the severity of LUTS and the symptoms of chronic prostatitis. They might reduce Qmax rate and lead to reduction of the f\/t PSA ratio and produce more severe inflammation causing increased seminal concentration of IL-1\u03b2 and IL-8.<\/jats:p>","DOI":"10.1159\/000455161","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T22:01:28Z","timestamp":1483567288000},"page":"449-455","source":"Crossref","is-referenced-by-count":7,"title":["Clinical and Biochemical Influence of Prostatic Stones"],"prefix":"10.1159","volume":"98","author":[{"given":"Tomislav","family":"Soric","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirnes","family":"Selimovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lada","family":"Bakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"\u0160imurina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Selthofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerka","family":"Dumic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,1,5]]},"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/455161","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/455161","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/455161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:07:40Z","timestamp":1745428060000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000455161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,5,30]]},"published-print":{"date-parts":[[2017,5,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000455161","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}