{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:28:16Z","timestamp":1747193296191,"version":"3.40.5"},"reference-count":0,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Surg"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background\/Aims:<\/i><\/b> Patients with hepatocellular carcinoma (HCC) beyond Milan criteria (MC) are not eligible for liver transplantation (LT). To elucidate prognostic factors significantly linked to recurrence beyond MC or death related to the liver, we evaluated the clinical features in a series of HCC patients within MC at baseline. <b><i>Methods:<\/i><\/b> We enrolled 255 na\u00efve HCC patients (\u226470 years) within the MC who underwent upper-gastrointestinal-endoscopy, and were treated with resection or radiofrequency ablation (62 years old [median]; male:female = 202:53; Child-Pugh A:B = 216:39). A finding of esophagogastric varices (EGV) with an enlarged tortuous or coil shape, and past history of treatment for EGV were classified as clinically significant. <b><i>Results:<\/i><\/b> Following curative therapy, there was a significant difference for both 3- and 5-year rates of recurrence beyond the MC or liver-related death between the patients with and without significant-EGV (42.8 and 64.3% vs. 25.2 and 41.2%, respectively; <i>p<\/i> < 0.001). Positive for significant-EGV, multiple tumor, and elevated levels of fucosylated-alpha-fetoprotein (\u226510%) and des-gamma-carboxy-prothrombin (\u2265100 mAU\/mL) were significant prognostic factors for recurrence beyond the MC or liver-related death in multivariate analysis (hazard ratio [HR] 2.020, <i>p<\/i> = 0.002; HR 1.880, <i>p<\/i> = 0.005; HR 1.626, <i>p<\/i> = 0.045; HR 1.722, <i>p<\/i> = 0.011, respectively). <b><i>Conclusion:<\/i><\/b> LT should be considered for EGV-positive patients with na\u00efve HCC and within the MC.<\/jats:p>","DOI":"10.1159\/000455330","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T22:01:24Z","timestamp":1487109684000},"page":"429-435","source":"Crossref","is-referenced-by-count":1,"title":["Importance of Screening for Esophagogastric Varices in Na\u00efve Hepatocellular Carcinoma Patients within Milan Criteria: Indicator for Liver Transplantation"],"prefix":"10.1159","volume":"34","author":[{"given":"Takamasa","family":"Kawakami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-0480","authenticated-orcid":false,"given":"Atsushi","family":"Hiraoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kojiro","family":"Michitaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Ninomiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Hirooka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Hiasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,2,15]]},"container-title":["Digestive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/455330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/455330","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/455330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:09:17Z","timestamp":1745428157000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000455330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,8,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000455330","archive":["Portico"],"relation":{},"ISSN":["0253-4886","1421-9883"],"issn-type":[{"type":"print","value":"0253-4886"},{"type":"electronic","value":"1421-9883"}],"subject":[],"published":{"date-parts":[[2017]]}}}