{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:12:00Z","timestamp":1768446720869,"version":"3.49.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> Our aim was to observe factors associated with <i>IL13<\/i> rs20541 polymorphism and other factors with or without allergic comorbidities such as subject-reported allergic rhinitis (AR) and\/or allergic conjunctivitis (AC) symptoms in adult asthmatics. <b><i>Methods:<\/i><\/b> A population-based sample of Finnish adult asthma patients (<i>n<\/i> = 1,156) and matched controls (<i>n<\/i> = 1,792) filled in a questionnaire. Asthma was diagnosed based on a typical history of asthma symptoms and lung function tests. Skin prick tests with 17 aeroallergens and blood tests including analysis of interleukin 13 (IL13) rs20541 (G\/A) genotypes were performed for a subsample (<i>n<\/i> = 193). <b><i>Results:<\/i><\/b> The proportion of asthmatics reporting AR was 61.9% and reporting AC was 40.7%. After adjustments, the presence of the <i>IL13<\/i> rs20541A- allele (OR 3.06, 95% CI 1.42-6.58, <i>p<\/i> = 0.004) or multisensitization (adjusted OR 4.59, 95% CI 1.48-14.26, <i>p<\/i> = 0.008) was associated with AR\/AC asthma. Nasal polyps and acetylsalicylic acid-exacerbated respiratory disease was also associated with AR\/AC asthma. <b><i>Conclusions:<\/i><\/b> Adult AR\/AC asthma could putatively be a phenotype, characterized by the presence of atopic and\/or eosinophilic factors and a high prevalence of the <i>IL13<\/i> rs20541A- allele. Studies on the mechanisms behind this and in other populations are needed.<\/jats:p>","DOI":"10.1159\/000456009","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T22:02:01Z","timestamp":1489010521000},"page":"123-128","source":"Crossref","is-referenced-by-count":17,"title":["Self-Reported Allergic Rhinitis and\/or Allergic Conjunctivitis Associate with <b><i>IL13<\/i><\/b> rs20541 Polymorphism in Finnish Adult Asthma 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