{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:31:10Z","timestamp":1776850270811,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>Theophylline has been extensively used in neonatal medicine in the management of apnea and bradycardia in premature infants [1]. Several authors have indicated that serum theophylline concentrations between 6 and 12 pg\/ml are safe and effective [2, 3] and that a maintenance dose of 2 mg\/kg every 12 h is needed to obtain these concentrations [2].\nWe recently observed a neonate whose theophylline dosing requirements were unusually high during continuous gastric suction but decreased markedly after the gastric suction was discontinued.<\/jats:p>","DOI":"10.1159\/000457050","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:07:34Z","timestamp":1502471254000},"page":"280-283","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Continuous Gastric Suction on Theophylline Clearance in a Newborn"],"prefix":"10.1159","author":[{"given":"Henry R.","family":"Boer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Gal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:31:29Z","timestamp":1776846689000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457050","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}