{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:31:12Z","timestamp":1776850272987,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>Although promazine has been used in obstetrics for over 20 years, its effects upon hemodynamic and acid-base conditions of steady-state pregnant sheep and fetus has not been sufficiently investigated. To study these effects, 10 experiments were performed in 5 ewes and their fetuses. Promazine (1 mg\/kg\/4 min) was administered intravenously to the ewes. Significant maternal changes included: reduction in hemoglobin from 9.1 \u00b1 0.43 to 8.4 \u00b1 0.43 g\/100 ml at 120 min, O(2) content from 12.1 \u00b1 0.61 to 10.8 \u00b1 0.59 vol% at 90 min, O(2) saturation from 9.7 \u00b1 2.58 to 95.4 \u00b1 2.80% at 15 min, and blood pressure from 86.1 \u00b1 4.94 to 74.1 \u00b1 2.55 mm Hg at 45 min. The heart rate increased from 84 \u00b1 2.64 to 100 \u00b1 5.03 beats\/min at 120 min. The uterine blood flow remained unchanged. The fetus developed mild metabolic acidosis as manifested by the reduction in pH from 7.375 \u00b1 0.008 to 7.35 \u00b1 0.005 at 45 min. No other fetal hemodynamic changes were observed. The significance of these findings is discussed.<\/jats:p>","DOI":"10.1159\/000457053","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:07:34Z","timestamp":1502471254000},"page":"302-310","source":"Crossref","is-referenced-by-count":0,"title":["Hemodynamic and Acid-Base Effects of Promazine on Unanesthetized Pregnant Sheep and Fetus"],"prefix":"10.1159","author":[{"given":"J.","family":"Ayromlooi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:31:30Z","timestamp":1776846690000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457053","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}