{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:33:43Z","timestamp":1776850423372,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>Hair copper and zinc contents were measured in 95 handicapped children aged from 4 to 17 years and 48 age- and sex-matched control children. The patients consisted of 5 groups: children untreated with anticonvulsants (n = 7), those treated with phenytoin and ph\u00e9nobarbital (n = 32), those treated with phenytoin, ph\u00e9nobarbital and diazepam (n = 18), those treated with diazepam alone (n = 16) and those treated with ph\u00e9nobarbital alone (n = 12). The patients were all institutionalized in the same medical care unit and received the same diet, containing decreased amounts of copper (75% of control) and sufficient amounts of zinc. The patients belonging to all of the 5 groups had less amounts of hair copper (p &lt; 0.05) and erythrocyte hemoglobin (p &lt; 0.01) in comparison to controls. The patients receiving diazepam alone or in addition to other anticonvulsants had significantly less hair zinc content (p &lt; 0.05) in comparison to controls or other patient groups. Thus, diazepam seemed to have an adverse effect, producing zinc deficiency.<\/jats:p>","DOI":"10.1159\/000457341","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:07:48Z","timestamp":1502471268000},"page":"381-387","source":"Crossref","is-referenced-by-count":4,"title":["Hair Copper and Zinc Concentrations in Handicapped Children Treated with Anticonvulsants"],"prefix":"10.1159","author":[{"given":"Tetsuo","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akimasa","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Matsukura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:33:47Z","timestamp":1776846827000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457341","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}