{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:34:03Z","timestamp":1776850443851,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>The effects of pharmacologic doses of dexamethasone, betamethasone, and\ncortisone given to pregnant rats on gestation days 12 and 13 were studied in mothers and\nfetuses on gestation day 21. Dexamethasone and betamethasone treatment resulted in a\nsignificant decrease in maternal and fetal weight gain, occurrence of cleft palate and\nomphalocele, and impaired growth of fetal heart, liver, adrenals, kidneys, and skeletal\nmuscle. Cortisone produced fewer developmental defects and less impairment of growth of\nfetal weight and other organs. Corynebacterium kutscheri infections occurred in pregnant\nrats treated with dexamethasone but not in rats treated with betamethasone or cortisone.\nThe analogues had widely different effects on organ growth and on the ratios of organ\nweight to body weight. The findings indicate that proportionate growth of fetal organs and\nbody weight is disturbed by glucocorticoid treatment in rats.<\/jats:p>","DOI":"10.1159\/000457394","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:07:41Z","timestamp":1502471261000},"page":"89-105","source":"Crossref","is-referenced-by-count":37,"title":["Disproportionate Growth of Organs and Body Weight\nfollowing Glucocorticoid Treatment of the Rat Fetus"],"prefix":"10.1159","author":[{"given":"H.","family":"David Mosier Jr.","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyle C.","family":"Dearden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina A.","family":"Jansons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalinda C.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy S.","family":"Biggd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:34:01Z","timestamp":1776846841000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457394","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}