{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:34:19Z","timestamp":1776850459536,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>A 3-year-old male with inflammatory bowel disease and hypogammaglobulinemia\nwas found to have decreased T lymphocyte function. His serum was shown to\ndepress normal T cell proliferative responses to phytohemagglutinin. Incorporation of lithium\nchloride to in vitro cultures enhanced autologous lymphocyte responses to phytohemagglutinin.\nSince lithium acts by inhibiting cAMP production, the child\u2019s lymphocytes\nwere postulated to have increased levels of cAMP. Both lymphocytes and serum were\nshown to contain elevated levels of cAMP. In vivo therapy with lithium citrate was initiated\nand enhanced T cell numbers and function were observed concomitantly. Serum\ncAMP was also reduced to normal levels. The patient showed initially marked clinical\nimprovement as assessed by mood, weight gain, and diminution of diarrhea. This clinical\nimprovement was unfortunately not sustained despite the continued improvement in\nimmune parameters and cAMP levels.<\/jats:p>","DOI":"10.1159\/000457430","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:07:53Z","timestamp":1502471273000},"page":"116-128","source":"Crossref","is-referenced-by-count":4,"title":["An Immiinodef\u00eccient Child with Inflammatory Bowel\nDisease: Involvement of Cyclic Nucleotides and Effects of\nLithium"],"prefix":"10.1159","author":[{"given":"William","family":"Borkowsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Shenkman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Suleski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Sansaricq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Siegal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rochelle","family":"Hirschhorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smithwick","family":"Elizabeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baron","family":"Shopsin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"Snyderman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:34:13Z","timestamp":1776846853000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457430","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}