{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:34:37Z","timestamp":1776850477811,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>To test our hypotheses that the hemodynamic response to\ncocaine may be altered during pregnancy, cocaine (0.33\nmg\/kg\/min) was infused intravenously to chronically catheterized\npregnant and nonpregnant female rats. Cardiac output\nand regional blood flow were measured, and cocaine concentrations\nin plasma and tissues, as well as plasma cholinesterase\nactivity were determined. Results were compared between\npregnant and nonpregnant groups. Cocaine produced a significant\ndecrease in heart rate, accompanied by a fall in cardiac\noutput, and decreased cerebral, myocardial, and placental\nblood flow in pregnant rats. The plasma cocaine concentration\nin pregnant animals was lower than that of nonpregnant ones,\nbut tissue concentrations were similar in both groups. These\nresults indicate that pregnancy enhances cardiovascular responses\nto subtoxic doses of cocaine. There was little placental\ntransfer of cocaine with a fetal to maternal plasma concentration\nratio of 0.28.<\/jats:p>","DOI":"10.1159\/000457467","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:08:22Z","timestamp":1502471302000},"page":"69-79","source":"Crossref","is-referenced-by-count":16,"title":["Pregnancy Alters the\nHemodynamic Responses to\nCocaine in the Rat"],"prefix":"10.1159","author":[{"given":"Hisayo O.","family":"Morishima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuaki","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward D.","family":"Miller jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:34:25Z","timestamp":1776846865000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457467","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}