{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:34:32Z","timestamp":1776850472040,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>Atrial natriuretic peptide (ANP) is a hormone involved in\nfluid and blood pressure homeostasis. We studied the effects\nof left-to-right shunting through a patent ductus arteriosus on\nblood pressure changes and plasma ANP concentrations in\nnewborn piglets. In five experimental piglets, the ductus arteriosus\nwas bathed with PGEl and infiltrated with formalin to\nmaintain its patency. In four age-matched control piglets, the\nductus arteriosus was ligated. Plasma ANP concentrations and\nblood pressure determinations were obtained prior to (baseline)\nand 25 \u00b1 1 h (day 1), and 48 \u00b1 1 h (day 2) after surgery.\nRadionuclide-microsphere determinations of left-to-right patent\nductus arteriosus shunts were performed on days 1 and 2\nin the 5 piglets with a patent ductus arteriosus. Plasma ANP\nconcentrations were significantly elevated in the left atrium on\nday 1 and the right atrium on day 2 in the PDA piglets. No\ncorrelation was demonstrated between plasma ANP concentrations\nand right or left atrial pressures. We conclude that left\nand right plasma atrial ANP concentrations are significantly\nelevated in newborn piglets with left-to-right patent ductus\narteriosus shunts.<\/jats:p>","DOI":"10.1159\/000457477","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:08:22Z","timestamp":1502471302000},"page":"155-160","source":"Crossref","is-referenced-by-count":1,"title":["Atrial Natriuretic Peptide in\nNewborn Piglets with a Patent\nDuctus arteriosus"],"prefix":"10.1159","author":[{"given":"Thomas A.","family":"Malone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara S.","family":"Stonestreet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Goddard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Sicard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Werner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:34:21Z","timestamp":1776846861000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457477","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}