{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:57:38Z","timestamp":1787162258762,"version":"build-2736575974"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>Indomethacin lowers neonatal cerebral perfusion immediately\nafter intravenous administration. It is important to elucidate\nwhether this reduction is mediated by inhibition of production\nof prostaglandins, especially prostacyclin, which plays an\nimportant role in the autoregulation of the neonatal cerebral\nvascular bed. We studied changes in cerebral blood flow by\nserial measurements of temporal mean flow velocity in the\nanterior cerebral artery (TMFY-ACA), relative cerebral vascular\nresistance (R-cer), and prostaglandins (measured as\nchanges in thiobarbituric acid reactive substances concentration;\nTBARS) after a therapeutic dose of 0.1 mg\/kg indomethacin\nadministered intravenously for noninvasive closure of\npatent ductus arteriosus. TMFV-ACA decreased and R-cer\nincreased immediately after the indomethacin administration\nwith a sustained recovery to preindomethacin values. The\nTBARS concentrations, however, did not change during the\nstudy period. We conclude that the present study suggests that\na therapeutic dose of 0.1 mg\/kg of indomethacin has no\nimpact on prostaglandin metabolism.<\/jats:p>","DOI":"10.1159\/000457540","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:08:12Z","timestamp":1502471292000},"page":"45-53","source":"Crossref","is-referenced-by-count":2,"title":["Is There a Relationship between\nIndomethacin-Induced Reduction\nin Neonatal Cerebral Blood Flow\nVelocity and Prostaglandin\nProduction?"],"prefix":"10.1159","author":[{"given":"Frank","family":"van Bel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diny","family":"van Zoeren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst","family":"Houdkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"M. Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:34:57Z","timestamp":1776846897000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457540","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}