{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:53:48Z","timestamp":1787165628421,"version":"build-2736575974"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>The effect of repeated doses of indomethacin on mean peak velocity\n(MPV) and time-averaged mean velocity in the middle cerebral artery was\nassessed in 10 ventilated neonates with a patent ductus arteriosus using\ncolour\/duplex Doppler technique prior to, and 10, 30, and 120 min after\nthe first and the third dose. Velocities were significantly reduced up to\n120 min after the first dose. The third dose resulted in a significant reduction\nin MPV at 10 and 30 min following treatment. This reduction was\nhalf of that observed after the first dose. Systemic blood pressure (BP) and\nheart rate did not change significantly after each separate dose. However,\nby the third dose, mean and diastolic BP were significantly increased from\npretreatment levels. The attenuated response of cerebral blood flow (CBF)\nvelocities to the third dose of indomethacin compared with the first dose is\nprobably related to altered haemodynamics. Indomethacin should be used\ncautiously in infants with other conditions which are known to decrease\nCBF such as hypotension, hypocarbia and polycythaemia.<\/jats:p>","DOI":"10.1159\/000457546","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:08:12Z","timestamp":1502471292000},"page":"100-106","source":"Crossref","is-referenced-by-count":47,"title":["Effect of Indomethacin on\nCerebral Blood Flow Velocities in\nVery Low Birth Weight Neonates\nwith a Patent Ductus Arteriosus"],"prefix":"10.1159","author":[{"given":"A.","family":"Ohlsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bottu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Govan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Myhr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:34:52Z","timestamp":1776846892000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457546","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}