{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:35:09Z","timestamp":1776850509489,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>The pharmacokinetic parameters of paracetamol were studied\nafter 15 min intravenous infusion of 15 mg\/kg of propacetamol\n(Prodafalgan\u00ae) in 5 neonates aged less than 10 days and 7\ninfants aged between 1 and 12 months. Blood was sampled at\n0,0.5,2 and 6 h after the first intravenous infusion of propacetamol.\nThe infants aged less than 10 days had higher plasma\nconcentrations of paracetamol, a longer half-life (3.5 vs. 2.1 h)\nand a lower plasma clearance (0.149 vs. 0.365 l\/h\/kg) than the\nolder children. Dose simulations were performed on the basis\nof individual data of each child in order to obtain steady-state\nplasma concentrations between 4 and 18 mg\/1 permitting the\nbest antipyretic effect for each child. In infants aged less than\n10 days a 15 mg\/kg dose of propacetamol four times a day (i.e.\n30 mg\/kg\/day paracetamol) is sufficient, corresponding to the\ndosage recommended by the French pharmacopoeia. On the\nother hand, double the dosage, nearer to the American dosage,\nis necessary for children aged over 10 days.<\/jats:p>","DOI":"10.1159\/000457553","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:08:44Z","timestamp":1502471324000},"page":"129-134","source":"Crossref","is-referenced-by-count":58,"title":["Pharmacokinetics of Paracetamol\nin the Neonate and Infant after\nAdministration of Propacetamol\nChlorhydrate"],"prefix":"10.1159","author":[{"given":"Elisabeth","family":"Autret","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Dutertre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Breteau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie-Pierre","family":"Jomille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Furet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Laugier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:34:50Z","timestamp":1776846890000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457553","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}