{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:35:15Z","timestamp":1776850515803,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>Yin Zhi Huang (YZH) is a decoction of four plants which is\nwidely used in Asia to treat neonatal jaundice. This study\ncompares the ability of ph\u00e9nobarbital and the individual herbs\ncomprising YZH, Artemisia, Gardenia, Rheum, and Scutellaria\nbaicalensis, to induce hepatic drug and bilirubin metabolizing\nenzymes in rats. Herbal decoctions (30 ml\/kg\/day) or\nph\u00e9nobarbital (60 mg\/kg\/day) were administered for 5 days.\nOnly ph\u00e9nobarbital increased cytochrome P-450 levels whereas\nGardenia slightly decreased levels. Artemisia, Rheum and\nph\u00e9nobarbital increased bilirubin glucuronyl transferase activity.\nGlucuronidation of a-naphthol was increased by Gardenia\nand ph\u00e9nobarbital, whereas Artemisia and Rheum were\nineffective inducers. Ph\u00e9nobarbital was the most effective\ninducer of glutathione-S-transferase (GSHT) activity. Ph\u00e9nobarbital\nand Gardenia both induced \u2206(5)-3-ketosteroid isomerase\nactivity, a marker for the Ya subunit of GSHT responsible\nfor intracellular bilirubin transport in liver. The selective\npatterns of enzyme induction suggest potential value for using\nspecific plant decoctions to modify drug and bilirubin metabolic\npathways.<\/jats:p>","DOI":"10.1159\/000457561","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:08:44Z","timestamp":1502471324000},"page":"186-194","source":"Crossref","is-referenced-by-count":18,"title":["Induction of Hepatic Bilirubin and Drug\nMetabolizing Enzymes by Individual\nHerbs Present in the Traditional\nChinese Medicine, Yin Zhi Huang"],"prefix":"10.1159","author":[{"given":"Jie","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"P. Wennberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:34:54Z","timestamp":1776846894000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457561","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}