{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:35:14Z","timestamp":1776850514598,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>Endothelins (ETs), recently discovered and highly vasoactive\nsubstances, have been implicated in the pathogenesis of various\nperinatal problems, such as preeclampsia, intrauterine\ngrowth retardation, intraventricular hemorrhage, pulmonary\nhypertension and necrotizing enterocolitis. Although fetal ET\nlevels have been measured at birth, reference ET values for\nhealthy newborns in the first days of life have not been established.\nThe purpose of this study was to determine in normal\nhealthy neonates ET 1-21 plasma values on day 1 and 4 postpartum\nand to investigate possible changes after adaptation of\nthe newborn to extrauterine life. The study comprised 20\nhealthy full-term neonates, born after vaginal delivery (n =\n10), or cesarean section (CS; n = 10) because of a previous CS.\nVenous blood was drawn on day 1 and 4 from all neonates and\nET 1-21 levels were determined in the plasma by radioimmunoassay\n(Amersham kit RPA 5559). ET 1-21 values were on\nday 1 11.83 \u00b1 2.39pmol\/l (n = 20) and on day 4 9.45 \u00b1\n1.88 pmol\/l (n = 20). The statistical analysis showed a significant\nreduction of plasma ET levels on day 4 (p = 0.004), but no\ninfluence of the mode of delivery on plasma ET levels. In conclusion\nirrespective of the mode of delivery the high ET 1-21\nplasma levels on day 1 postpartum are significantly reduced\non day 4 of life.<\/jats:p>","DOI":"10.1159\/000457562","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:08:44Z","timestamp":1502471324000},"page":"195-198","source":"Crossref","is-referenced-by-count":7,"title":["Endothelin 1-21 Plasma Levels on\nthe First and Fourth Postpartum\nDay in Normal Full-Term Neonates"],"prefix":"10.1159","author":[{"given":"Ariadne","family":"Malamitsi-Puchner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Economou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Sevastiadou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodoros","family":"Efstathopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Nicolopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:34:53Z","timestamp":1776846893000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457562","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}