{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:47:42Z","timestamp":1777531662045,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>Tin protoporphyrin (SnPP) and analogs are being studied as possible agents for\nthe prevention of neonatal hyperbilirubinemia through inhibition of heme oxygenase.\nBecause SnPP is a photosensitizer, we studied its role in the photogeneration of carbon\nmonoxide (CO) from organic compounds in vitro. Generation of CO occurred in the presence\nof 5 \\iM SnPP and cool white light (19 pW\/cnri\/nm or 29 W\/m2) from SnPP alone,\nhuman serum albumin, glucose, histidine, ethanolamine, medium-chain triglycerides, the\nreduced form of nicotinamide-adenine dinucleotide phosphate (NADPH), and human plasma.\nMore detailed studies with human serum albumin and NADPH established that the\nphotogeneration of CO is nearly linear with time and irradiance. It is curvilinear with respect\nto the SnPP concentration at the concentrations tested, and it is dependent on the presence\nof O2 in the reactor headspace. Cool white light generated less CO from human serum\nalbumin and NADPH than equidistantly placed blue and green phototherapy light sources.\nComparison of SnPP with other metalloporphyrin heme oxygenase inhibitors indicates that\ntin mesoporphyrin is most and zinc protoporphyrin least photoreactive.<\/jats:p>","DOI":"10.1159\/000457630","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:08:52Z","timestamp":1502471332000},"page":"112-124","source":"Crossref","is-referenced-by-count":36,"title":["In vitro Generation of Carbon Monoxide from\nOrganic Molecules and Synthetic Metalloporphyrins\nMediated by Light"],"prefix":"10.1159","author":[{"given":"Hendrik J.","family":"Vremana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Gillman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey R.","family":"Downum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:35:16Z","timestamp":1776846916000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457630","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}