{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:35:58Z","timestamp":1776850558004,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>The pattern of drug use in preterm newborns admitted to neonatal intensive\ncare units (NICU) was monitored as part of a large multicenter study including a representative\nsample of Italian NICUs. All prescriptions from the admission of the mother through\nthe 1st week of the neonate\u2019s life were carefully documented on standardized ad hoc forms,\nwith particular attention to the timing and duration of each prescribed drug. The 706 babies\nincluded in the surveillance program received an average of 1.7 drugs during the early neonatal\nperiod, and were exposed to an average of 3.4 drugs over the whole perinatal period.\nThe most commonly used drugs postnatally were vitamins, antibiotics (ampicillin, gentamicin\nand tobramycin), methylxanthines (aminophylline and caffeine), ph\u00e9nobarbital and\nfurosemide. The frequency and intensity of the use of these drugs appears to be directly\nrelated to the severity of the clinical status, and inversely related to birth weight and gestational\nage.<\/jats:p>","DOI":"10.1159\/000457657","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:09:10Z","timestamp":1502471350000},"page":"1-7","source":"Crossref","is-referenced-by-count":17,"title":["Early Neonatal Drug Utilization in Preterm Newborns in\nNeonatal Intensive Care Units"],"prefix":"10.1159","author":[{"family":"Italian Collaborative Group on Preterm Delivery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:35:25Z","timestamp":1776846925000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457657","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}