{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:51:36Z","timestamp":1777866696885,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>The effectiveness of activated charcoal as an adjunct to phototherapy in\nreducing plasma bilirubin levels was studied in the jaundiced rat. The administration of\ncharcoal either by feeding orgavage was effective in reducing plasma bilirubin levels in both\nthe adult and suckling jaundiced rat. The combination of charcoal feeding and phototherapy\nin the adult rat was additive in that the bilirubin levels were significantly lower when\ncompared to levels of the rats given charcoal alone. Plasma bilirubin levels were significantly\nreduced in the suckling jaundiced rat given either charcoal or charcoal together with\nphototherapy, however, the combination of treatments did not appear to be additive. These\ndata suggest that charcoal could be a useful adjunct to phototherapy by binding bilirubin in\nthe intestinal lumen and reducing the potential for the enterohepatic circulation of unconjugated\nbilirubin. Charcoal combined with phototherapy may also reduce the intensity of\nphototherapy needed to effectively lower plasma bilirubin levels.<\/jats:p>","DOI":"10.1159\/000457723","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:09:04Z","timestamp":1502471344000},"page":"12-20","source":"Crossref","is-referenced-by-count":10,"title":["Activated Charcoal as an Adjunct to\nPhototherapy for Neonatal Jaundice"],"prefix":"10.1159","author":[{"given":"David R.","family":"Davis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger A.","family":"Yeary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:09:28Z","timestamp":1777540168000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457723","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}