{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:51:24Z","timestamp":1777866684634,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>Caffeine has been shown to markedly alter growth hormone (GH), thyroid\nstimulating hormone (TSH), and thyroid hormones in animal studies. Similar studies in\nthe human are lacking. To determine the effect of theophylline treatment on endocrine\nfunction in neonates with apnea, 10 infants were studied prospectively pretreatment,\nimmediately following therapeutic blood levels of theophylline, at 2, 4, and 6 weeks\nthereafter and finally 2 weeks after discontinuation of theophylline. T(4), free T(4), T(3), GH,\nand basal and stimulated TSH were measured at each study period. Results show no\nsignificant difference consequent to theophylline therapy on basal thyroid or GH secretion\nand thyrotropin-releasing hormone (TRH) induced TSH response at any study interval.\nWe conclude there is no evidence to suspect abnormality occurring in growth, thyroid\nfunction and GH secretion in neonates receiving theophylline for breathing disorders.<\/jats:p>","DOI":"10.1159\/000457731","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:08:58Z","timestamp":1502471338000},"page":"73-80","source":"Crossref","is-referenced-by-count":4,"title":["Theophylline Treatment in the Neonate with Apnea: Effect on Growth Hormone, Thyroid Hormone and TRH Induced TSH Secretion"],"prefix":"10.1159","author":[{"given":"Lynne D.","family":"Willett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A.","family":"Huseman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Varma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457731","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:09:36Z","timestamp":1777540176000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457731","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}