{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:51:28Z","timestamp":1777866688972,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>The effect of patent ductus arteriosus (PDA) and its therapy on the pharmacokinetic\ndisposition of gentamicin in very low birth weight neonates was studied.\nTwenty-four neonates weighing less than 1,500 g with PDA were compared to 16 patients\nwithout PDA. Patients with PDA had significantly greater apparent volumes of distribution\n(0.64 \u00b1 0.20 vs. 0.41 \u00b1 0.08 1\/kg; p &lt; 0.001) and serum half-life (8.49 \u00b1 2.69 vs.\n6.23 \u00b1 1.92 h; p &lt; 0.01). The total body clearance was not significantly different between\nthe two groups (56 \u00b1 20 ml\/kg\/h with PDA vs. 50 \u00b1 24 ml\/kg\/h without PDA). In\naddition, 7 patients were studied before and after PDA closure. The apparent volume of\ndistribution fell in every case (p = 0.02). A statistically significant effect on clearance and\nhalf-life was not found. These findings suggest that PDA increases extracellular fluid\nvolume, but does not affect glomerular filtration rate adversely. Additionally, serum gentamicin\nconcentrations must be reevaluated after PDA closure in premature neonates.<\/jats:p>","DOI":"10.1159\/000457735","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:08:58Z","timestamp":1502471338000},"page":"107-117","source":"Crossref","is-referenced-by-count":19,"title":["Effect of Patent Ductus arteriosus on Gentamicin Pharmacokinetics in Very Low Birth Weight (&lt;1,500 g) Babies"],"prefix":"10.1159","author":[{"given":"Kristi L.","family":"Watterberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. William","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Aldrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Angelus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:09:35Z","timestamp":1777540175000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457735","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}