{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:18:02Z","timestamp":1787163482308,"version":"build-2736575974"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Pharmacol Ther"],"abstract":"<jats:p>Prophylactic closure of the patent ductus arteriosus (PDA) has been recommended\nas a means of decreasing early respiratory distress, and thereby chronic respiratory\nsequelae in the very low birth weight (VLBW) neonate. This study was undertaken\nto evaluate some possible mechanisms for the observed failure of early indomethacin\ntherapy to achieve such improvement. 24 VLBW infants with \u00e9chocardiographie evidence\nof PDA were randomized to receive either indomethacin or placebo at 48 h of life;\nand then they were studied for clinical, metabolic and laboratory signs of ductal constriction\nand\/or reopening. Early indomethacin conferred no improvement in respiratory\nsequelae. However, this was not secondary to a short-term therapeutic failure. Prophylactic\nindomethacin, even in the VLBW infant, was successful in decreasing dilator prostaglandin\nproduction, and probably in closing the PDA and in decreasing the number of\nrecurrences. The implications are that even with effective ductal constriction, overall\nmorbidity is not affected.<\/jats:p>","DOI":"10.1159\/000457771","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:09:26Z","timestamp":1502471366000},"page":"393-404","source":"Crossref","is-referenced-by-count":22,"title":["Failure of Prophylactic Indomethacin\nto Improve the Outcome\nof the Very Low Birth Weight Infant"],"prefix":"10.1159","author":[{"given":"Cathy","family":"Hammerman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Strates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Komar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim-chi","family":"Bui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Developmental Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000457771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:09:50Z","timestamp":1777540190000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000457771","archive":["Portico"],"relation":{},"ISSN":["0379-8305","2504-2505"],"issn-type":[{"value":"0379-8305","type":"print"},{"value":"2504-2505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}