{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:29:07Z","timestamp":1790659747593,"version":"4.1.0"},"reference-count":11,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>Cushing\u2019s syndrome is a rare endocrine disorder that comprises a large group of signs and symptoms resulting from chronic exposure to excess corticosteroids. Most cases of Cushing\u2019s syndrome are due to increased adrenocorticotropic hormone production from a pituitary adenoma, which is referred to as Cushing\u2019s disease. Most of the signs and symptoms are nonspecific and common in the general population, making a diagnosis often challenging. However, several dermatological manifestations, such as fragile skin, easy bruising, and reddish purple striae, are more discriminatory. Because uncontrolled Cushing\u2019s syndrome of any etiology is associated with substantial morbidity, including increased cardiovascular disease and mortality, it is important to make an early diagnosis. Unfortunately, median delays of 2 years to diagnosis have been reported. We report a case of a woman who had multiple dermatological findings, including facial plethora, easy bruising, violaceous striae, hirsutism, and acne, the latter 2 signs reflecting androgen excess. Of interest, our patient presented with a chief complaint of hair loss, a common complaint in the general population that occurs with a greater frequency in patients with Cushing\u2019s disease and is attributed to androgenetic alopecia, but it is rarely the presenting symptom.<\/jats:p>","DOI":"10.1159\/000457898","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T22:01:45Z","timestamp":1487714505000},"page":"45-50","source":"Crossref","is-referenced-by-count":12,"title":["A Case Report of Cushing\u2019s Disease Presenting as Hair Loss"],"prefix":"10.1159","volume":"9","author":[{"given":"Emily\u00a0G.","family":"Lefkowitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack\u00a0P.","family":"Cossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u00a0B.","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-014-0569-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68699-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0125"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304050-00003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.19.5.0346"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0272"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4158\/EP15914.OR"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.04.008"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2001.00124.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2005.02.001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3126"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/457898","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/457898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/457898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:32:29Z","timestamp":1745429549000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000457898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,4,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000457898","archive":["Portico"],"relation":{},"ISSN":["1662-6567"],"issn-type":[{"value":"1662-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]}}}