{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:58:20Z","timestamp":1772805500042,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Leukemic infiltration of the optic nerve is relatively rare. While previously described in acute leukemia, the infiltration in our case represents central nervous system (CNS) metastasis of Burkitt-type lymphoma that developed as a complication of solid-organ transplantation, resulting in a bilateral infiltrative optic neuropathy with sequential, bilateral central retinal artery occlusion (CRAO) and devastating vision loss. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The medical record, serial ophthalmic examination findings, clinical course, and imaging including magnetic resonance imaging (MRI), fundus photographs, and fluorescein angiography of a single patient were retrospectively reviewed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; MRI demonstrated multifocal cortical and leptomeningeal CNS involvement, including the left optic nerve. Serial fundus examination\/photography and fluorescein angiography showed that despite urgent whole-brain irradiation and systemic chemotherapy, CNS disease progressed to bilateral optic nerve infiltration and CRAO with no light perception vision in both eyes. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; CRAO can occur as a devastating and irreversible complication of lymphoproliferative optic nerve infiltration.<\/jats:p>","DOI":"10.1159\/000458414","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T22:12:47Z","timestamp":1490220767000},"page":"229-234","source":"Crossref","is-referenced-by-count":6,"title":["Bilateral Central Retinal Artery Occlusion Associated with Bilateral Lymphoproliferative Infiltrative Optic Neuropathy"],"prefix":"10.1159","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-7167","authenticated-orcid":false,"given":"Philip J.","family":"DeSouza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia G.","family":"Hooten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Lack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishak J.","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2005.03.015"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21911"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000346346"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703806"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2006.00596.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000339722"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.087338"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006290032052"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-453084"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3129\/i07-133"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(85)90148-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080070139051"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2011.02616.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2009.204"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700701"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.891224"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(83)80013-X"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01299-X"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.1.93"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-05-615872"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/458414","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/458414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/458414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:56:45Z","timestamp":1745427405000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000458414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,9,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000458414","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"value":"2296-4681","type":"print"},{"value":"2296-4657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}