{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:16:44Z","timestamp":1792653404249,"version":"4.5.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> Early outcome predictors after delivery room cardiopulmonary resuscitation (CPR) of asphyxiated newborns are needed. <b><i>Objectives:<\/i><\/b> To investigate if cerebral (rScO<sub>2<\/sub>) and renal (rSrO<sub>2<\/sub>) tissue oxygen saturation 30 min after return of spontaneous circulation (ROSC) are different between surviving versus nonsurviving piglets with asphyxia-induced cardiac arrest and CPR. Further, to investigate the relationship of rScO<sub>2<\/sub> and rSrO<sub>2<\/sub> to cardiac output (CO), blood pressure (BP), and biochemical variables 30 min and 4 h after ROSC. <b><i>Methods:<\/i><\/b> Anesthetized, mechanically ventilated piglets (1-3 days, 1.7-2.4 kg) were used. rScO<sub>2<\/sub>, rSrO<sub>2<\/sub>, SpO<sub>2<\/sub>, right common carotid artery flow, and arterial BP were measured continuously. CO was measured with echocardiography. The piglets were asphyxiated until cardiac arrest and resuscitated. Piglets that survived 4 h after ROSC (<i>n<\/i> = 12) were compared with piglets that died before planned euthanasia at 4 h (<i>n<\/i> = 13). Left ventricular, and kidney and brain tissue lactate were analyzed. Correlations between variables were assessed. <b><i>Results:<\/i><\/b> Thirty minutes after ROSC, median rSrO<sub>2<\/sub> (43% [<i>n<\/i> = 10] vs. 25% [<i>n<\/i> = 2], <i>p<\/i> = 0.003) but not rScO<sub>2<\/sub> (46% [41-55] [<i>n<\/i> = 10] vs. 40% [22-45] [<i>n<\/i> = 5], <i>p<\/i> = 0.08) was higher in survivors than in nonsurvivors. Arterial lactate was negatively correlated and pH positively correlated with rScO<sub>2<\/sub> and rSrO<sub>2<\/sub>. Left ventricular, but not kidney or brain lactate was negatively correlated with rScO<sub>2<\/sub> and rSrO<sub>2<\/sub>. There was no correlation between CO or BP and rScO<sub>2<\/sub> or rSrO<sub>2<\/sub>. <b><i>Conclusions:<\/i><\/b> Despite satisfactory CO and BP vital organ oxygenation can be poor. Tissue oxygen saturation, pH, and lactate, as measures of anaerobic metabolism, may reflect vital organ oxygenation and outcome.<\/jats:p>","DOI":"10.1159\/000458515","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T21:02:09Z","timestamp":1491426129000},"page":"80-86","source":"Crossref","is-referenced-by-count":3,"title":["Association between Brain and Kidney Near-Infrared Spectroscopy and Early Postresuscitation Mortality in Asphyxiated Newborn Piglets"],"prefix":"10.1159","volume":"112","author":[{"given":"Anne Lee","family":"Solev\u00e5g","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg M.","family":"Schm\u00f6lzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt","family":"Nakstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3166-5254","authenticated-orcid":false,"given":"Ola Didrik","family":"Saugstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7141-1523","authenticated-orcid":false,"given":"Po-Yin","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70072-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1073044"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.240.323"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00517-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2014.12.011"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.12.042"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2006.09.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1396692"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0987"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000412"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.07.007"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2016.06.014"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000275560"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.09.060"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12357"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2174\/156720209788970090"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.10.041"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2011.03549.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000351346"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80023-4"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000053"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/458515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/458515","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/458515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:57:16Z","timestamp":1745427436000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000458515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,6,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000458515","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.4818229","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}