{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:26:07Z","timestamp":1777868767948,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>In copper-deficient rats, oral intubation of copper increases the rate of ceruloplasmin\nsynthesis without affecting general synthesis of plasma or liver proteins. It also restores the\nenzyme from half to full activity. Copper given by injection at doses commonly employed has\nadditional nonspecific effects on protein synthesis and in some strains of rats produces severe\nhemolysis. In contrast to deficient rats, in normal rats copper does not elevate plasma\nceruloplasmin unless hemolysis also occurs. Thus, at least in deficiency, copper availability\ncontrols the rate of synthesis, activation, and plasma concentration of cemloolasmin.<\/jats:p>","DOI":"10.1159\/000458625","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:10:49Z","timestamp":1502471449000},"page":"23-35","source":"Crossref","is-referenced-by-count":53,"title":["Copper Regulation of Ceruloplasmin in Copper-Deficient Rats"],"prefix":"10.1159","author":[{"given":"Maria C.","family":"Linder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Houle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan R.","family":"Moor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura E.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000458625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:39:35Z","timestamp":1777552775000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000458625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000458625","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}