{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:29:15Z","timestamp":1745468955990,"version":"3.40.4"},"reference-count":49,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> Clusters of cardiovascular risk (CVR) factors are associated with an increased risk of developing cardiovascular diseases (CVDs). This cross-sectional study assessed the associations between classic CVR factor clusters and inflammatory markers in Brazilian adolescents. <b><i>Methods:<\/i><\/b> Measurements included anthropometric, clinical and biochemical parameters and selected inflammatory markers in 487 adolescents (236 boys\/251 girls; 12.06 \u00b1 1.41 years). <b><i>Results:<\/i><\/b> After stratifying the population by gender and adjusting for potential confounding variables, principal component analysis was performed and it produced 5 independent components in both genders: adiposity, glucose metabolism, blood pressure, high-density lipoprotein (HDL)\/triacylglycerols (TG), and cholesterol\/low-density lipoprotein. Glucose metabolism was inversely associated with interleukin-1\u03b2 (IL-1\u03b2) in both genders (<i>r<\/i> = -0.026; <i>r<\/i> = -0.021); blood pressure was inversely associated with tumor necrosis factor alpha (TNF-\u03b1) in girls (<i>r<\/i> = -0.046); HDL\/TG was positively associated with interleukin-6 in girls (<i>r<\/i> = 0.012), with IL-1\u03b2 (<i>r<\/i> = 0.010) TNF-\u03b1 (<i>r<\/i> = 0.045) in boys, and inversely associated with adiponectin in both genders (<i>r<\/i> = -0.015; <i>r<\/i> = -0.013). <b><i>Conclusion:<\/i><\/b> The results suggest that lipid metabolism alterations, as potential early events in the development of CVDs, have a strong link to the inflammatory process, in contrast to other clusters of risk factors.<\/jats:p>","DOI":"10.1159\/000458767","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T21:01:32Z","timestamp":1496955692000},"page":"259-267","source":"Crossref","is-referenced-by-count":3,"title":["Clustered 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