{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:26:16Z","timestamp":1777868776397,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Hepatic bilirubin (Bil-GT) and paranitrophenol glucuronyl transferase\n(PNP-GT) activities were measured in 26 subjects with Gilbert\u2019s syndrome (GS) and in one\nsubject with a Crigler-Najjar type 2. Firstly, the results allowed us to distinguish three\ngroups of patients in GS. In the first group, Bil-GT activity decreased by 25% of that of the\ncontrols and PNP-GT activity was normal. In the second group, Bil-GT decreased by 25%\nof that of the controls and PNP-GT decreased by 50% of that of the controls. In the third\ngroup, Bil-GT decreased by 50% of that of the controls and PNP-GT activity was normal.\nSecondly, the results showed in the Crigler-Najjar type 2 that Bil-GT activity was 25% of\nthat of the controls and PNP-GT was 10% of that of the controls. From these results the\nfollowing hypothesis has been raised: (1) the subjects of the third GS group were probably\nheterozygous to the homozygous disease which affected the subjects of the first GS group,\nand (2) the subjects of the second GS group were most likely heterozygous to the homozygous\ndisease which affected our Crigler-Najjar type 2. However, in the present state of\nour knowledge, the scheme of GS classification which we propose requires confirmation.<\/jats:p>","DOI":"10.1159\/000458848","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:11:18Z","timestamp":1502471478000},"page":"97-107","source":"Crossref","is-referenced-by-count":16,"title":["Bilirubin and Paranitrophenol Glucuronyl Transferase Activities of the Liver in Patients with Gilbert\u2019s Syndrome. An Attempt at a Biochemical Breakdown of the Gilbert\u2019s Syndrome"],"prefix":"10.1159","author":[{"given":"C.","family":"Auclair","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hakim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Boivin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Troube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Boucherot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000458848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:40:20Z","timestamp":1777552820000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000458848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000458848","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}