{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:26:20Z","timestamp":1777868780395,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>The activities of 12 enzymes, many related to ornithine metabolism, were\nmeasured in rat submaxillary gland, submaxillary gland tumors and pancreas. In submaxillary\ngland, the activities of arginase, ornithine aminotransferase, pyrroline-5-carboxylate\nreductase and glutamine synthetase were high, but no ornithine transcarbamylase or\nproline oxidase could be detected. In the fetal submaxillary gland, arginase was at almost\nadult levels while ornithine aminotransferase reached 50% of its adult value postnatally.\nSubmaxillary tumors deviated from their cognate tissue by lower levels of amino acid\nmetabolizing enzymes and by high concentrations of thymidine kinase. In pancreas, none\nof the pyrroline-5-carboxylate metabolizing enzymes were as high as in either liver or\nsubmaxillary gland. The outstanding activities were those of \u03b3-glutamyl transpeptidase and\nglutamate dehydrogenase. Although arginase activities in submaxillary gland and pancreas\nwere quantitatively similar, they differed qualitatively: submaxillary gland contained the\nsame variant as liver while the pancreatic isozymes resembled those of other nonhepatic\ntissues.<\/jats:p>","DOI":"10.1159\/000458896","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:11:15Z","timestamp":1502471475000},"page":"471-480","source":"Crossref","is-referenced-by-count":6,"title":["Amino Acid Metabolizing Enzymes in Rat Submaxillary Gland, Normal or Neoplastic, and in Pancreas"],"prefix":"10.1159","author":[{"given":"Annemarie","family":"Herzfeld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M.","family":"Raper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000458896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:40:44Z","timestamp":1777552844000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000458896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000458896","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}