{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:26:19Z","timestamp":1777868779495,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Mitochondrial preparations isolated from rat ventral prostate were capable\nof oxidizing isocitrate by way of NADP isocitrate dehydrogenase (NADP-IDH) and NADIDH.\nNAD-IDH activity required ADP for activation. The pH responses for NAD-IDH\nand NADP-IDH were quite different. The results indicated that two different enzymes\nwere involved in the NAD- and NADP-IDH activities. Indirect evidence indicated that\nNADPH-NAD transhydrogenase activity might also be involved in the mitochondrial\npathway for isocitrate oxidation. NADP-IDH activity was significantly greater than NADIDH\nactivity. The oxidation of isocitrate through IDH activity was coupled to the cytochrome\nsystem by NADPH- and NADH-cytochrome c reductase activities. Citrate, via\nisocitrate, oxidation proceeded at a much slower rate suggesting that aconitase activity\ncould be limiting in the oxidation of citrate. In comparison to other tissues, the prostate\noxidative enzyme activities are considerably lower. The results suggest that the accumulation\nof high prostate citrate levels is not due to a limitation imposed by a lack of IDH activity\nin prostate mitochondria.<\/jats:p>","DOI":"10.1159\/000458902","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:11:18Z","timestamp":1502471478000},"page":"495-506","source":"Crossref","is-referenced-by-count":25,"title":["Mitochondrial Isocitrate Dehydrogenase and Isocitrate Oxidation of Rat Ventral Prostate"],"prefix":"10.1159","author":[{"given":"L.C.","family":"Costello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Stacey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000458902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:40:43Z","timestamp":1777552843000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000458902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000458902","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}