{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:26:23Z","timestamp":1777868783283,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>D-Aspartate oxidase was isolated from the pig thyroid\ngland and purified over 600 times. The enzyme was obtained in an\ninactive form of apoenzyme and was activated by FAD. It was specific\ntowards the D-form of aspartic acid, had no effect on the L-form, and\nwas also inactive towards other monocarboxylic D-amino acids. The\nenzyme was only slightly active towards D-glutamate. The Michaelis\nconstant based on the Lineaweaver-Burk plot was 5 mmol\/1. The optimum pH was 8.7.\nD-Aspartate oxidase was inhibited by KCN in concentrations varying from 0.05 to 1\nmmol\/1. The biological role of this enzyme in the thyroid gland is discussed.<\/jats:p>","DOI":"10.1159\/000458923","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:11:30Z","timestamp":1502471490000},"page":"80-89","source":"Crossref","is-referenced-by-count":10,"title":["D-Aspartate Oxidase in the Thyroid Gland"],"prefix":"10.1159","author":[{"given":"Leokadia","family":"Jaroszewicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000458923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:40:59Z","timestamp":1777552859000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000458923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000458923","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}