{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:26:36Z","timestamp":1777868796060,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Thyroid hormones control the levels of the lysosomal enzymes, cholesterol esterase\nand hyaluronidase, in rat liver, skeletal muscle and skin. Activities of these enzymes\ndecreased to approximately 40-50% of normal levels in liver cell fractions, skeletal muscle\nhomogenates and skin homogenates from thyroidectomized rats. Treatment of hypophysectomized\nrats with L-triiodothyronine increased the activities of cholesterol esterase and hyaluronidase\napproximately 2-fold in liver cell fractions. The low levels of hyaluronidase and\ncholesterol esterase in thyroidectomized rats may account for the accumulation of mucopolysaccharides\nin skin and for the elevation of serum cholesterol levels in hypothyroid\npatients.<\/jats:p>","DOI":"10.1159\/000459140","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:11:55Z","timestamp":1502471515000},"page":"1-7","source":"Crossref","is-referenced-by-count":20,"title":["A Possible Explanation of Myxedema and Hypercholesterolemia\nin Hypothyroidism: Control of Lysosomal\nHyaluronidase and Cholesterol Esterase by Thyroid Hormones"],"prefix":"10.1159","author":[{"given":"George N.","family":"DeMartino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred L.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000459140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:42:21Z","timestamp":1777552941000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000459140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000459140","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}