{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:26:36Z","timestamp":1777868796061,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>The urinary output of \u03b3-glutamyl-transpeptidase (\u03b3GT) and of N-acetyl-\u03b2-D-glucosaminidase\n(NAG) was studied in rats with \u2018two-kidney Goldblatt hypertension\u2019 3-6, 16-19\nand 30-33 weeks after eliciting high blood pressure. \u03b3GT excretion rate of normotensive males\nwas higher than that of females, while the activity of the renal tissue was on the same level.\n\u03b3GT output of hypertensive males was elevated in the early and in the middle stages of the\ndisease, it was subnormal in the late stage. In females \u03b3GT output increased in animals with\nexcessively high blood pressure (&gt; 200 mm Hg) only. \u03b3GT output correlated with the tissue\nactivity in males only. In all animals there was an inverse, linear correlation between tissue\n\u03b3GT activity and the hydroxyproline content. The pattern of the NAG output was similar to\nthat of \u03b3GT, however, excretion of NAG showed no sex differences and remained high in the\nlate stage of the disease, too. Nephrosclerosis was less pronounced in female Goldblatt rats\nthan in males.<\/jats:p>","DOI":"10.1159\/000459144","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:11:55Z","timestamp":1502471515000},"page":"32-42","source":"Crossref","is-referenced-by-count":8,"title":["Enzymuria (the Output of Gamma-Glutamyl-Transpeptidase\nand of N-Acetyl-Beta-D-Glucosaminidase) in the Course of\nExperimental Renovascular Hypertension"],"prefix":"10.1159","author":[{"given":"M.","family":"M\u00e1lyusz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000459144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:42:22Z","timestamp":1777552942000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000459144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000459144","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}