{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:26:38Z","timestamp":1777868798457,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>An improved method has been developed for the detection of heterozygotes for\nfeline and human mucopolysaccharidosis VI. Arylsulfatase-A and -B activities were assayed\nin leukocyte extracts following separation of the enzymes by batch chromatography on DEAE\ncellulose. Determination of arylsulfatase-B specific activities did not permit accurate heterozygote\nidentification, whereas the arylsulfatase-A to arylsulfatase-B activity ratio discriminated\nall 16 obligate heterozygotes for the feline and human disorders.<\/jats:p>","DOI":"10.1159\/000459176","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:12:20Z","timestamp":1502471540000},"page":"206-210","source":"Crossref","is-referenced-by-count":11,"title":["An Improved Method for Heterozygote Identification in Feline\nand Human Mucopolysaccharidosis VI, Arylsulfatase-B\nDeficiency"],"prefix":"10.1159","author":[{"given":"Margaret M.","family":"McGovern","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah T.","family":"Vine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Haskins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Desnick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000459176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:42:37Z","timestamp":1777552957000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000459176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000459176","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}