{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:26:54Z","timestamp":1777868814191,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Three different \u03b2-galactosidases in the\nhuman small intestine have been partially purified and\ncharacterized. Quantitative methods, applicable on\nsingle jejunal biopsies, were then elaborated to study\nthe enzymatic alteration in adult low lactase activity\nand in congenital lactase deficiency. The activity of\nbrush-border lactase was 10-20 times reduced in\nadults with specific low lactase activity. The residual\nenzyme had the same properties as in adults with persistently\nhigh lactase activity. In three patients with\ncongenital lactase deficiency, on the other hand, no\nbrush-border lactase at all was demonstrable, while a very weak activity was\nfound in a fourth patient. The activities of lysosomal acid \u03b2-galactosidase and cytosol\nhetero-\u03b2-galactosidase were not altered.<\/jats:p>","DOI":"10.1159\/000459416","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:12:52Z","timestamp":1502471572000},"page":"84-102","source":"Crossref","is-referenced-by-count":20,"title":["Intestinal \u03b2-Galactosidases in Adult Low Lactase Activity1 and\nin Congenital Lactase Deficiency"],"prefix":"10.1159","author":[{"given":"Nils-Georg","family":"Asp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Dahlqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000459416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:43:59Z","timestamp":1777553039000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000459416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000459416","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}