{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:26:59Z","timestamp":1777868819742,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzymol Biol Clin"],"abstract":"<jats:p>(1) Alkaline phosphatases were\npresent in all subcellular fractions obtained by\nultracentrifugation of all the tissues examined.\n(2) The highest specific activities (mU\/mg protein) were found in the microsomal fractions,\nthe lowest in the supernatant, with the exception of the mammary tumour examined. (3) A\ndifferent thermostability of the enzymes in the\nvarious fractions pointed to the presence of isoenzymes; a biphasic curve gave\nevidence of the simultaneous presence of at least two isoenzymes in some particulate\nstructures. (4) There was no specific thermolabile pattern of alkaline phosphatases in\nthe malignant tissues examined, assuming the method used is valid for establishing\nsuch differences.<\/jats:p>","DOI":"10.1159\/000459517","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:12:59Z","timestamp":1502471579000},"page":"76-87","source":"Crossref","is-referenced-by-count":1,"title":["The Ultrastructural Localization of Alkaline\nPhosphatase Isoenzymes in Some Normal\nand Malignant Cells"],"prefix":"10.1159","author":[{"given":"V.","family":"Lustig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Kellen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzymologia biologica et clinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000459517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:44:27Z","timestamp":1777553067000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000459517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000459517","archive":["Portico"],"relation":{},"ISSN":["0425-1423","2504-2572"],"issn-type":[{"value":"0425-1423","type":"print"},{"value":"2504-2572","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}