{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T22:08:35Z","timestamp":1781474915446,"version":"3.54.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>We examined the effect of repeated cold (RC) stress on cyclophosphamide (CPA)-induced cystitis\/bladder pain in mice, in relation to macrophage activity. CPA, given i.p. at 400 mg\/kg, caused bladder pain symptoms accompanying cystitis in both unstressed and RC-stressed mice, which were prevented by the macrophage inhibitor minocycline. A low dose, that is, 200 mg\/kg, of CPA still produced bladder pain symptoms in unstressed but not RC-stressed mice. Lipopolysaccharide-induced cytokine production in peritoneal macrophages from RC-stressed mice was less than that from unstressed mice. Thus, RC stress appears to reduce CPA-induced bladder pain in mice, which may be associated with the decreased macrophage activity.<\/jats:p>","DOI":"10.1159\/000461588","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T22:01:42Z","timestamp":1488492102000},"page":"286-290","source":"Crossref","is-referenced-by-count":4,"title":["Repeated Cold Stress Reduces Cyclophosphamide-Induced Cystitis\/Bladder Pain and Macrophage Activity in Mice"],"prefix":"10.1159","volume":"99","author":[{"given":"Maho","family":"Tsubota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyoshi","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Hiruma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Saeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaya","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Sekiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Funakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsufumi","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)00057-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.41.69"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15992.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.33.1545"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.29.479"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-4-52"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b16-00343"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00169-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053\/eujp.1998.0105"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02060.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.11.003"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.08.1108"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01535.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-016-0149-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000144142.26242.f3"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00086.2006"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/461588","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/461588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/461588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:16:41Z","timestamp":1745428601000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000461588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":16,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2017,3,24]]},"published-print":{"date-parts":[[2017,3,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000461588","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}