{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:32:10Z","timestamp":1790188330356,"version":"4.1.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Abstract:&lt;\/i&gt;&lt;\/b&gt; Preterm infants present higher risk of non-optimal neurodevelopmental outcome. Fetal and postnatal growth, in particular head circumference (HC), is associated with neurodevelopmental outcome. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; We aimed to calculate the relationship between HC at birth, HC delta Z-score (between birth and hospital discharge), and non-optimal neurodevelopmental outcome at 2 years of corrected age in preterm infants. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Surviving infants born \u226434 weeks of gestation were included in the analysis. The relationship between the risk of being non-optimal at 2 years and both HC at birth and HC growth was assessed. The 2 Z-scores were considered first independently and then simultaneously to investigate their effect on the risk of non-optimality using a generalized additive model. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 4,046 infants with both HC measures at birth and hospital discharge were included. Infants with small HC at birth (Z-score &lt;-2 SD), or presenting suboptimal HC growth (dZ-score &lt;-2 SD), are at higher risk of non-optimal neurodevelopmental outcome at 2 years (respectively OR 1.7 [95% CI 1.4-2] and OR 1.4 [95% CI 1.2-1.8]). Interestingly, patients cumulating small HC Z-score at birth (-2 SD) and presenting catch-down growth (HC dZ-score [-2 SD]) have a significantly increased risk for neurocognitive impairment (OR &gt;2) while adjusting for gestational age, twin status, sex, and socioeconomic information. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; HC at birth and HC dZ-score between birth and hospital discharge are synergistically associated to neurodevelopmental outcome at 2 years of corrected age, in a population-based prospective cohort of preterm infants born \u226434 weeks of gestation.<\/jats:p>","DOI":"10.1159\/000464272","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T21:05:19Z","timestamp":1494277519000},"page":"122-129","source":"Crossref","is-referenced-by-count":37,"title":["Fetal and Postnatal Head Circumference Growth: Synergetic Factors for Neurodevelopmental Outcome at 2 Years of Age for Preterm Infants"],"prefix":"10.1159","volume":"112","author":[{"given":"M\u00e9lanie","family":"Sicard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Nusinovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Hanf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Guellec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Ancel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Gascoin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Roz\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Flamant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7961"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0091"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.11.014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12811"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-1821"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1368"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1187"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2011.049"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.04.009"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12319"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16285-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-305464"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(02)00436-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/22.3.313"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0913"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-000834"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00079.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62049-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-3258"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2671"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000351020"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-0129"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/464272","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/464272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:32:50Z","timestamp":1745429570000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000464272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,8,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000464272","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.4982930","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}