{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:13:26Z","timestamp":1780359206321,"version":"3.54.1"},"reference-count":26,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Several studies report that fluid removal rate (FRR) above 10-13 mL\/h\/kg is associated with increased mortality in haemodialysis (HD) patients. &lt;b&gt;&lt;i&gt;Aim:&lt;\/i&gt;&lt;\/b&gt; The aims of this study are to assess the influence of moderate FRR on survival in a cohort of prevalent dialysis patients with various dialysis session times and to challenge the FRR thresholds associated with increased mortality risk reported previously. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Interdialytic weight gain (IDWG) and FRR (calculated from ultrafiltration [UF], target weight, and session time prescriptions) were studied in 190 prevalent dialysis patients (female: 42%, mean age: 69.5 years, median vintage: 40.2 months, diabetes: 34.7%, loop diuretic prescription: 5.8%) and averaged during the final quarter of 2010. Patient survival was analysed using Kaplan-Meier and Cox-multivariate analyses. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The median IDWG, median session time, and median FRR were 2.33 kg (-0.54-4.57), 5.0 h (3.9-8.0 h), 6.8 mL\/h\/kg (1.3-16.7), respectively, and FRR was \u226510 mL\/h\/kg in 11.6% of the patients. The Kaplan-Meier analysis showed decreased patient survival when the FRR was above the median (6.8 mL\/h\/kg; &lt;i&gt;p&lt;\/i&gt; = 0.012). The FRR was found to be independently associated with increased mortality (hazard ratio 1.15 [95% CI 1.02-1.29]; &lt;i&gt;p&lt;\/i&gt; = 0.027) using stepwise Cox proportional hazard regression analysis, including age, vintage, gender, body mass index (BMI), serum albumin level, \u03b22-microglobulin level, cardiovascular and diabetes history, and session time. Online haemodiafiltration did not change this result. The role of residual renal function was unlikely because 74% of the patients had a vintage of &gt;18 months, a minority (5.8%) were prescribed loop diuretics (a surrogate of significant urine output) and \u03b22-microglobulin level was not different in patients who were below or above the FRR median. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; We concluded that the FRR threshold above which there is an increased mortality is lower than what has been reported (7.8 mL\/h\/kg). It raises the question of the hazard of fluid removal and intermittence of standard HD.<\/jats:p>","DOI":"10.1159\/000464346","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T22:50:56Z","timestamp":1490309456000},"page":"89-97","source":"Crossref","is-referenced-by-count":14,"title":["Even a Moderate Fluid Removal Rate during Individualised Haemodialysis Session Times Is Associated with Decreased Patient Survival"],"prefix":"10.1159","volume":"44","author":[{"given":"Charles","family":"Chazot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Vo-Van","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie","family":"Lorriaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Deleaval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Mayor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Hurot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Jean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.383"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm466"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000186"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03900808"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04470709"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9820470"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000337101"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002750"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(98)70164-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl487"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00850112"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000349931"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.12.017"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12411212"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp168"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.09314.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.807362"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010030280"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012080875"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460070053041"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000188"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq724"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.5.884"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.213"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft078"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000170069"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/464346","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/464346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/464346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:33:20Z","timestamp":1745429600000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000464346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,6,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000464346","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}