{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:31:06Z","timestamp":1745469066318,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> The utility of circadian cortisol variation in estimating the degree of hypercortisolemia in different forms of endogenous Cushing syndrome (CS) has not been evaluated in children yet. <b><i>Methods:<\/i><\/b> A retrospective cohort study, including children who underwent surgery due to CS (<i>n<\/i> = 115), was divided into children with a pituitary adenoma (Cushing disease) (<i>n<\/i> = 88), primary adrenal CS (<i>n<\/i> = 21), or ectopic adrenocorticotropin- or corticotropin-releasing hormone (ACTH-\/CRH)-secreting tumors (<i>n<\/i> = 6). Circadian plasma cortisol measurements were obtained at 11: 30 p.m. and at midnight, and at 7: 30 and 8: 00 a.m. The ratios between the morning and late-night concentrations were calculated. <b><i>Results:<\/i><\/b> Plasma cortisol early-morning and midnight (AM\/PM) ratios negatively correlated with 24-h urinary free cortisol (UFC) collections among the full study population and in each of the individual etiologies. Plasma ACTH concentrations positively correlated with plasma cortisol AM\/PM ratios among patients with ACTH-independent CS. Finally, patients with primary pigmented nodular adrenocortical disease showed no correlation between UFC collections and the plasma cortisol AM\/PM ratio, in contrast with other etiologies for primary adrenal CS, which showed a strong negative correlation between them. <b><i>Conclusion:<\/i><\/b> Our study shows the association between the plasma cortisol AM\/PM ratio and the degree of hypercortisolemia in children with CS.<\/jats:p>","DOI":"10.1159\/000464463","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T21:01:50Z","timestamp":1493154110000},"page":"295-300","source":"Crossref","is-referenced-by-count":3,"title":["Circadian Plasma Cortisol Measurements Reflect Severity of Hypercortisolemia in Children with Different Etiologies of Endogenous Cushing Syndrome"],"prefix":"10.1159","volume":"87","author":[{"given":"Amit","family":"Tirosh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya\u00a0B.","family":"Lodish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charalampos","family":"Lyssikatos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Belyavskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios\u00a0Z.","family":"Papadakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantine\u00a0A.","family":"Stratakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,4,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61375-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-59-1-161"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000212"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0125"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2402"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2617"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2853"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000134829"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02918.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-5-1-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/79238"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.10.006"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1518"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/464463","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/464463","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/464463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:33:59Z","timestamp":1745429639000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000464463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,7,4]]},"published-print":{"date-parts":[[2017,6,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000464463","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2017]]}}}